| Autor: |
Hatay GH; Biomedical Engineering Institute, Bogazici University, Rasathane Cad, Kandilli Campus, Kandilli Mah., 34684, Istanbul, Turkey., Yildirim M; Biomedical Engineering Institute, Bogazici University, Rasathane Cad, Kandilli Campus, Kandilli Mah., 34684, Istanbul, Turkey., Ozturk-Isik E; Biomedical Engineering Institute, Bogazici University, Rasathane Cad, Kandilli Campus, Kandilli Mah., 34684, Istanbul, Turkey. esin.ozturk@boun.edu.tr. |
| Abstrakt: |
The purpose of this study was to apply compressed sensing method for accelerated phosphorus MR spectroscopic imaging ( 31 P-MRSI) of human brain in vivo at 3T. Fast 31 P-MRSI data of five volunteers were acquired on a 3T clinical MR scanner using pulse-acquire sequence with a pseudorandom undersampling pattern for a data reduction factor of 5.33 and were reconstructed using compressed sensing. Additionally, simulated 31 P-MRSI human brain tumor datasets were created to analyze the effects of k-space sampling pattern, data matrix size, regularization parameters of the reconstruction, and noise on the compressed sensing accelerated 31 P-MRSI data. The 31 P metabolite peak ratios of the full and compressed sensing accelerated datasets of healthy volunteers in vivo were similar according to the results of a Bland-Altman test. The estimated effective spatial resolution increased with reduction factor and sampling more at the k-space center. A lower regularization parameter for both total variation and L1-norm penalties resulted in a better compressed sensing reconstruction of 31 P-MRSI. Although the root-mean-square error increased with noise levels, the compressed sensing reconstruction was robust for up to a reduction factor of 10 for the simulated data that had sharply defined tumor borders. As a result, compressed sensing was successfully applied to accelerate 31 P-MRSI of human brain in vivo at 3T. |
