Methylation status of homeobox genes in common human cancers.

Autor: Rodrigues MF; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Esteves CM; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Xavier FC; Department of Stomatology, School of Dentistry, Federal University of Bahia, Salvador, Brazil., Nunes FD; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. Electronic address: fadnunes@uol.com.br.
Jazyk: angličtina
Zdroj: Genomics [Genomics] 2016 Dec; Vol. 108 (5-6), pp. 185-193. Date of Electronic Publication: 2016 Nov 05.
DOI: 10.1016/j.ygeno.2016.11.001
Abstrakt: Approximately 300 homeobox loci were identified in the euchromatic regions of the human genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many of these genes play important roles in embryonic development and cell differentiation. Dysregulation of homeobox gene expression is a frequent occurrence in cancer. Accumulating evidence suggests that as genetics disorders, epigenetic modifications alter the expression of oncogenes and tumor suppressor genes driving tumorigenesis and perhaps play a more central role in the evolution and progression of this disease. Here, we described the current knowledge regarding homeobox gene DNA methylation in human cancer and describe its relevance in the diagnosis, therapeutic response and prognosis of different types of human cancers.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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