Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents.
Autor: | Chaves JDS; Departamento de Química, ICE, Universidade Federal de Juiz de Fora, 36036-330, Juiz de Fora, MG, Brazil., Tunes LG; Centro de Pesquisas René Rachou - Fundação Oswaldo Cruz, 30190-002, Belo Horizonte, MG, Brazil., de J Franco CH; Departamento de Química, ICE, Universidade Federal de Juiz de Fora, 36036-330, Juiz de Fora, MG, Brazil., Francisco TM; Departamento de Física, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil., Corrêa CC; Departamento de Química, ICE, Universidade Federal de Juiz de Fora, 36036-330, Juiz de Fora, MG, Brazil., Murta SMF; Centro de Pesquisas René Rachou - Fundação Oswaldo Cruz, 30190-002, Belo Horizonte, MG, Brazil., Monte-Neto RL; Centro de Pesquisas René Rachou - Fundação Oswaldo Cruz, 30190-002, Belo Horizonte, MG, Brazil., Silva H; Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil., Fontes APS; Departamento de Química, ICE, Universidade Federal de Juiz de Fora, 36036-330, Juiz de Fora, MG, Brazil., de Almeida MV; Departamento de Química, ICE, Universidade Federal de Juiz de Fora, 36036-330, Juiz de Fora, MG, Brazil. Electronic address: mauro.almeida@ufjf.edu.br. |
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Jazyk: | angličtina |
Zdroj: | European journal of medicinal chemistry [Eur J Med Chem] 2017 Feb 15; Vol. 127, pp. 727-739. Date of Electronic Publication: 2016 Oct 24. |
DOI: | 10.1016/j.ejmech.2016.10.052 |
Abstrakt: | The current anticancer and antileishmanial drug arsenal presents several limitations concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines, which encourages the urgent need to search for new alternatives. Inspired by the fact that gold(I)-based compounds are promising antitumoral and antileishmanial drug candidates, we synthesized novel gold(I) complexes containing phosphine and 5-phenyl-1,3,4-oxadiazole-2-thione and evaluated their anticancer and antileishmanial activities. Synthesis was performed by reacting 5-phenyl-1,3,4-oxadiazole-2-thione derivatives with chloro(triphenylphosphine)gold(I) and chloro(triethylphosphine)gold(I). The novel compounds were characterized by infrared, Raman, 1 H, 13 C nuclear magnetic resonance, high-resolution mass spectra, and x-ray crystallography. The coordination of the ligands to gold(I) occurred through the exocyclic sulfur atom. All gold(I) complexes were active at low micromolar or nanomolar range with IC (Copyright © 2016 Elsevier Masson SAS. All rights reserved.) |
Databáze: | MEDLINE |
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