Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis.

Autor: Silva JA; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil j.azvedo@gmail.com.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil j.azvedo@gmail.com., Lima SC; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil., Addobbati C; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil., Moura R; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil., Brandão LA; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Departamento de Patologia, Universidade Federal de Pernambuco, Recife, PE, Brasil., Pancoto JA; Universidade Federal do Espírito Santo, São Mateus, ES, Brasil., Donadi EA; Divisão de Imunologia Clínica, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil., Crovella S; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil., Sandrin-Garcia P; Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.
Jazyk: angličtina
Zdroj: Genetics and molecular research : GMR [Genet Mol Res] 2016 Oct 24; Vol. 15 (4). Date of Electronic Publication: 2016 Oct 24.
DOI: 10.4238/gmr15048008
Abstrakt: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C domain 1 (IFIH1) activates and modulates IFN responses through its caspase recruitment domain. In this study, we analyzed four IFIH1 single nucleotide polymorphisms (SNPs): rs6432714, rs10930046, rs1990760, and rs3747517, in 337 patients with SLE and 373 healthy individuals from southeast and northeast Brazil. Our results did not find an association between IFIH1 SNPs and SLE (P value >0.025 after Bonferroni's adjustment). However, meta-analysis of peer-reviewed articles from 2008 to 2015 and data from this study indicated an association between rs1990760 and SLE onset (P < 0.05). This is the first association analysis on IFIH1 polymorphisms and SLE susceptibility in Brazilian populations.
Databáze: MEDLINE
Externí odkaz: