Attention-Deficit/Hyperactivity Disorder symptoms coincide with altered striatal connectivity.

Autor: Oldehinkel M; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands., Beckmann CF; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands; Centre for Functional MRI of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom., Pruim RH; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands., van Oort ES; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands; MIRA Institute, University of Twente, Enschede, The Netherlands., Franke B; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands; Radboud University Medical Center, Departments of Human Genetics and Psychiatry, Nijmegen, The Netherlands., Hartman CA; University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands., Hoekstra PJ; University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands., Oosterlaan J; VU University Amsterdam, Department of Clinical Psychology, Section of Clinical Neuropsychology, Amsterdam, The Netherlands., Heslenfeld D; VU University Amsterdam, Department of Clinical Psychology, Section of Clinical Neuropsychology, Amsterdam, The Netherlands., Buitelaar JK; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands., Mennes M; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2016 Jul; Vol. 1 (4), pp. 353-363. Date of Electronic Publication: 2016 Apr 13.
DOI: 10.1016/j.bpsc.2016.03.008
Abstrakt: Background: Cortico-striatal network dysfunction in attention-deficit/hyperactivity disorder (ADHD) is generally investigated by comparing functional connectivity of the main striatal sub-regions (i.e., putamen, caudate, and nucleus accumbens) between an ADHD and a control group. However, dimensional analyses based on continuous symptom measures might help to parse the high phenotypic heterogeneity in ADHD. Here, we focus on functional segregation of regions in the striatum and investigate cortico-striatal networks using both categorical and dimensional measures of ADHD.
Methods: We computed whole-brain functional connectivity for six striatal sub-regions that resulted from a novel functional parcellation technique. We compared functional connectivity maps between adolescents with ADHD (N=169) and healthy controls (N=122), and investigated dimensional ADHD-related measures by relating striatal connectivity to ADHD symptom scores (N=444). Finally, we examined whether altered connectivity of striatal sub-regions related to motor and cognitive performance.
Results: We observed no case-control differences in functional connectivity patterns of the six striatal networks. In contrast, inattention and hyperactivity/impulsivity symptom scores were associated with increases in functional connectivity in the networks of posterior putamen and ventral caudate. Increased connectivity of posterior putamen with motor cortex and cerebellum was associated with decreased motor performance.
Conclusions: Our findings support hypotheses of cortico-striatal network dysfunction in ADHD by demonstrating that dimensional symptom measures are associated with changes in functional connectivity. These changes were not detected by categorical ADHD versus control group analyses, highlighting the important contribution of dimensional analyses to investigating the neurobiology of ADHD.
Databáze: MEDLINE
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