Adult Hematology and Clinical Chemistry Laboratory Reference Ranges in a Zimbabwean Population.

Autor: Samaneka WP; University of Zimbabwe-University of California San Francisco Collaborative Research Programme, Harare, Zimbabwe., Mandozana G; Department of Community Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Tinago W; Department of Community Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Nhando N; University of Zimbabwe-University of California San Francisco Collaborative Research Programme, Harare, Zimbabwe., Mgodi NM; University of Zimbabwe-University of California San Francisco Collaborative Research Programme, Harare, Zimbabwe., Bwakura-Dangarembizi MF; Department of Pediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Munjoma MW; University of Zimbabwe-University of California San Francisco Collaborative Research Programme, Harare, Zimbabwe.; Department of Obstetrics and Gynecology and Reproductive Health Sciences, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Gomo ZA; Department of Chemical Pathology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Chirenje ZM; University of Zimbabwe-University of California San Francisco Collaborative Research Programme, Harare, Zimbabwe.; Department of Obstetrics and Gynecology and Reproductive Health Sciences, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Hakim JG; University of Zimbabwe-University of California San Francisco Collaborative Research Programme, Harare, Zimbabwe.; Department of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2016 Nov 03; Vol. 11 (11), pp. e0165821. Date of Electronic Publication: 2016 Nov 03 (Print Publication: 2016).
DOI: 10.1371/journal.pone.0165821
Abstrakt: Background: Laboratory reference ranges used for clinical care and clinical trials in various laboratories in Zimbabwe were derived from textbooks and research studies conducted more than ten years ago. Periodic verification of these ranges is essential to track changes over time. The purpose of this study was to establish hematology and chemistry laboratory reference ranges using more rigorous methods.
Methods: A community-based cross-sectional study was carried out in Harare, Chitungwiza, and Mutoko. A multistage sampling technique was used. Samples were transported from the field for analysis at the ISO15189 certified University of Zimbabwe-University of California San Francisco Central Research Laboratory. Hematology and clinical chemistry reference ranges lower and upper reference limits were estimated at the 2.5th and 97.5th percentiles respectively.
Results: A total of 769 adults (54% males) aged 18 to 55 years were included in the analysis. Median age was 28 [IQR: 23-35] years. Males had significantly higher red cell counts, hemoglobin, hematocrit, and mean corpuscular hemoglobin compared to females. Females had higher white cell counts, platelets, absolute neutrophil counts, and absolute lymphocyte counts compared to males. There were no gender differences in eosinophils, monocytes, and absolute basophil count. Males had significantly higher levels of urea, sodium, potassium, calcium, creatinine, amylase, total protein, albumin and liver enzymes levels compared to females. Females had higher cholesterol and lipase compared with males. There are notable differences in the white cell counts, neutrophils, cholesterol, and creatinine kinase when compared with the currently used reference ranges.
Conclusion: Data from this study provides new country specific reference ranges which should be immediately adopted for routine clinical care and accurate monitoring of adverse events in research studies.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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