Increasing access to kidney transplantation for sensitized recipient through three-way kidney paired donation with desensitization: The first Indian report.

Autor:	Kute VB; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Patel HV; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Shah PR; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Modi PR; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Shah VR; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Rizvi SJ; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Pal BC; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Modi MP; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Shah PS; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Varyani UT; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Wakhare PS; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Shinde SG; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Ghodela VA; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Patel MH; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Trivedi VB; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India., Trivedi HL; Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Priya S Shah, Umesh T Varyani, Pavan S Wakhare, Saiprasad G Shinde, Viajay A Ghodela, Hargovind L Trivedi, Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad 380016, India.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2016 Oct 16; Vol. 4 (10), pp. 351-355.
DOI:	10.12998/wjcc.v4.i10.351
Abstrakt:	The combination of kidney paired donation (KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation (LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient. All recipients were discharged with normal and stable allograft function at 24 mo follow up. We believe that this is first report from India where three-way KPD exchange was performed with the combination of KPD and desensitization. The combination of desensitization protocol with KPD improves access and outcomes of LDKT. Competing Interests: Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
Databáze:	MEDLINE
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