[Comparative proteome analysis of blood plasma of patients with early-stage chronic cerebral ischemia].

Autor:	Kisrieva YS; Institute of Biomedical Chemistry, Moscow, Russia., Petushkova NA; Institute of Biomedical Chemistry, Moscow, Russia., Samenkova NF; Institute of Biomedical Chemistry, Moscow, Russia., Kuznetsova GP; Institute of Biomedical Chemistry, Moscow, Russia., Larina OV; Institute of Biomedical Chemistry, Moscow, Russia., Zavialova MG; Institute of Biomedical Chemistry, Moscow, Russia., Teryaeva NB; Burdenko Institute of Neurosurgery, Moscow, Russia., Belyaev AY; Burdenko Institute of Neurosurgery, Moscow, Russia., Karuzina II; Institute of Biomedical Chemistry, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Biomeditsinskaia khimiia [Biomed Khim] 2016 Jul; Vol. 62 (5), pp. 599-602.
DOI:	10.18097/PBMC20166205599
Abstrakt:	In the present study, we explored the technology of liquid chromatography-mass spectrometry (HPLC-MS/MS) for the proteome analysis of blood plasma of patients with early chronic cerebral ischemia. Analysis of mass-spectrometer data carried out in automatic mode using the software Progenesis LS-MS. As a result of this study identified 43 proteins. The differences identified in the study group compared with the control in 7 proteins. It was found that in the early stages of chronic cerebral ischemia proteome changes in blood plasma affect proteins related to the immune system, the system for the maintenance of hemostasis and lipid metabolism.
Databáze:	MEDLINE
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