Discovery of Anticancer Agents of Diverse Natural Origin.

Autor:	Kinghorn AD; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A. kinghorn.4@osu.edu.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A., DE Blanco EJ; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A., Lucas DM; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.; College of Medicine, The Ohio State University, Columbus, OH, U.S.A., Rakotondraibe HL; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A., Orjala J; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A., Soejarto DD; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.; Field Museum of Natural History, Chicago, IL, U.S.A., Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, U.S.A., Pearce CJ; Mycosynthetix, Inc., Hillsborough, NC, U.S.A., Wani MC; Research Triangle Institute, Research Triangle Park, NC, U.S.A., Stockwell BR; Department of Biological Sciences, Columbia University, New York, NY, U.S.A.; Department of Chemistry, Columbia University, New York, NY, U.S.A., Burdette JE; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A., Swanson SM; School of Pharmacy, University of Wisconsin-Madison, Madison, WI, U.S.A., Fuchs JR; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A., Phelps MA; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A., Xu L; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A., Zhang X; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.; College of Medicine, The Ohio State University, Columbus, OH, U.S.A., Shen YY; Eisai Inc., Andover, MA, U.S.A.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2016 Nov; Vol. 36 (11), pp. 5623-5637.
DOI:	10.21873/anticanres.11146
Abstrakt:	Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity. (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
Databáze:	MEDLINE
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