Platelet activating factor: A potential biomarker in acute coronary syndrome?

Autor: Palur Ramakrishnan AV; Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India., Varghese TP; Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India., Vanapalli S; Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India., Nair NK; Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India., Mingate MD; Department of Pharmacy Practice, JSS College of Pharmacy (Jagadguru Sri Shivarathreeswara University, Mysore), Udhagamandalam, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Cardiovascular therapeutics [Cardiovasc Ther] 2017 Feb; Vol. 35 (1), pp. 64-70.
DOI: 10.1111/1755-5922.12233
Abstrakt: Platelet activating factor (PAF) is a potent pro-inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and initiation and progression of atherosclerosis. The purpose of this article was to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress, and platelet reactivity. This review further provides information about PAF and its potential role as a key contributor to the pathogenesis of cardiovascular disorders.
(© 2016 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje