Participation of TLR2 and TLR4 in Cytokines Production by Patients with Symptomatic and Asymptomatic Chronic Chagas Disease.

Autor: Mendes da Silva LD; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil., Gatto M; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil., Miziara de Abreu Teodoro M; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil., de Assis Golim M; Flow Cytometry Laboratory, Hemocenter, Botucatu School of Medicine-UNESP, Botucatu, São Paulo, Brazil., Pelisson Nunes da Costa ÉA; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil., Capel Tavares Carvalho F; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil., Ramos Rodrigues D; Microbiology and Immunology Department, Bioscience Institute-UNESP, Botucatu, São Paulo, Brazil., Câmara Marques Pereira P; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil., Victoriano de Campos Soares ÂM; Microbiology and Immunology Department, Bioscience Institute-UNESP, Botucatu, São Paulo, Brazil., Calvi SA; Tropical Diseases Department, Botucatu Medical School - UNESP, Botucatu, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2017 Jan; Vol. 85 (1), pp. 58-65.
DOI: 10.1111/sji.12501
Abstrakt: Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a serious public health issue. Its evolution involves an acute stage, characterized by no specific symptoms, and the chronic stage during most individuals are asymptomatic, but about 30-40% of them become symptomatic presenting the cardiac or digestive disease. Host immune response mechanisms involved in symptomatic or asymptomatic chronic disease are not fully understood. The pro-inflammatory cytokines are crucial in host resistance. However, a fine control of this inflammatory process, by action of anti-inflammatory cytokines, is necessary to avoid tissue injury. This control was found to be responsible for no clinical manifestations in asymptomatic individuals. Toll-like receptors (TLRs) are extremely important in defining the cytokine profile released in response to a micro-organism. We found that patients with the cardiac form predominantly released the pro-inflammatory cytokines: IFN-γ, TNF-α and IL-17 with the involvement of both, TLR2 and TLR4. In contrast, patients with asymptomatic disease release predominantly the anti-inflammatory cytokines IL-10 and TGF-β, but also with TLR2 and TLR4 participation. The mechanisms by which stimulation of the same TLRs results in release of different pattern of cytokines, depending on the patients group that is being evaluated, are discussed.
(© 2016 The Foundation for the Scandinavian Journal of Immunology.)
Databáze: MEDLINE
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