Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections.

Autor: Vechkapova SO; Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. svetavech@yandex.ru., Zapara TA; Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Morozova EA; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Proskura AL; Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Schul'ts EE; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Tolstikova TG; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Ratushnyak AS; Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Oct; Vol. 161 (6), pp. 782-785. Date of Electronic Publication: 2016 Oct 26.
DOI: 10.1007/s10517-016-3509-9
Abstrakt: Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.
Databáze: MEDLINE
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