Interaction of Serum Antibodies from Breast Cancer Patients with Synthetic Peptides.

Autor: Podlesnykh SV; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation., Kolosova EA; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation., Shcherbakov DN; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation., Shaidurov AA; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation., Anisimov DS; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation., Ryazanov MA; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation., Johnston SA; Center for Innovations in Medicine, Biodesign Institute, Arizona State University, Tempe, AZ, USA., Shoikhet YN; Altai State Medical University, Barnaul, Russian Federation., Petrova VD; Altai Branch of the N. N. Blokhin Russian Cancer Research Center, Barnaul, Russian Federation., Lazarev AF; Altai Branch of the N. N. Blokhin Russian Cancer Research Center, Barnaul, Russian Federation., Chapoval AI; Russian-American Anti-Cancer Center, Altai State University, Barnaul, Russian Federation. andreichapoval@gmail.com.; Center for Innovations in Medicine, Biodesign Institute, Arizona State University, Tempe, AZ, USA. andreichapoval@gmail.com.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Oct; Vol. 161 (6), pp. 816-820. Date of Electronic Publication: 2016 Oct 26.
DOI: 10.1007/s10517-016-3519-7
Abstrakt: The blood serum of tumor patients contains antibodies recognizing tumor-associated antigens and other molecular products of tumor growth. We studied the interaction of blood antibodies from breast cancer patients with synthetic peptides that were applied on the microchip surface. The serum from healthy volunteers and breast cancer patients was shown to contain antibodies that interact with various peptides. Statistically significant between-group differences were observed in the level of binding with 122 informative peptides (0.01% of the total number of peptides on a microchip). Analysis of antibodies that interact with the peptide panel holds much promise for the diagnostics of breast cancer.
Databáze: MEDLINE
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