The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city.

Autor: Amrani-Midoun A; Biotechnology Department, Faculty of Sciences of Nature and Life, University of Oran 1 Ahmed Benbella, Oran, Algeria. Electronic address: dr.asma.amrani@gmail.com., Kiando SR; INSERM, UMR970 Paris Cardiovascular Research Center (PARCC), Paris F-75015, France; Paris-Descartes University, Sorbonne Paris Cité, Paris 75006, France., Treard C; INSERM, UMR970 Paris Cardiovascular Research Center (PARCC), Paris F-75015, France; Paris-Descartes University, Sorbonne Paris Cité, Paris 75006, France., Jeunemaitre X; INSERM, UMR970 Paris Cardiovascular Research Center (PARCC), Paris F-75015, France; Paris-Descartes University, Sorbonne Paris Cité, Paris 75006, France; AP-HP, Department of Genetics, Hôpital Européen Georges Pompidou, Paris F-75015, France., Bouatia-Naji N; INSERM, UMR970 Paris Cardiovascular Research Center (PARCC), Paris F-75015, France; Paris-Descartes University, Sorbonne Paris Cité, Paris 75006, France.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2016 Dec 15; Vol. 225, pp. 408-411. Date of Electronic Publication: 2016 Oct 11.
DOI: 10.1016/j.ijcard.2016.10.027
Abstrakt: Background: Many studies have investigated the role of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in essential hypertension (EH), but with conflicting results.
Aim: To determine the eventual association between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and hypertension in a sample of Algerian population from the Oran city.
Methods: A case-control study has been performed in 154 subjects including 82 hypertensives defined as subjects with elevated systolic blood pressure SBD≥140mmHg and or sustained diastolic blood pressure DBP≥90mmHg, and 72 normotensive subjects. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to detect the MTHFR C677T variant.
Results: We observe no significant differences between allelic and genotypic frequencies between cases and controls for C677T polymorphism (OR=1.51, 95% CI=0.89-2.56, P=0.13). Analyses adjusted for age, sex and body mass index improved the association level, though the association was still not significant (30% vs. 22%, OR=1.75, 95% CI=0.95-3.24, P=0.07).
Conclusion: This work showed that genetic polymorphism related to the MTHFR gene (C677T) is not associated with the risk of hypertension in this sample of Algerian population. Larger case-control samples are required to clearly assess the role of this genetic variant in EH.
(Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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