Epidemiological study of hepatitis B virus among prisoners with active tuberculosis in Central Brazil.

Autor:	Iglecias LM; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Puga MA; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Pompílio MA; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Teles SA; School of Nursing, Federal University of Goiás, Goiânia, Goiás, Brazil., Croda J; Federal University of Grande Dourados, Dourados, Mato Grosso do Sul , Oswaldo Cruz Foundation, Mato Grosso do Sul, Mato Grosso do Sul, Brazil., Lima LA; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Lago BV; Laboratory of Molecular Virology, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil., Martins RM; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil., Motta-Castro AR; Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Oswaldo Cruz Foundation, Mato Grosso do Sul, Mato Grosso do Sul, Brazil.
Jazyk:	angličtina
Zdroj:	The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2016 Nov; Vol. 20 (11), pp. 1509-1515.
DOI:	10.5588/ijtld.15.0743
Abstrakt:	Background: Due to environmental and social conditions inherent to incarceration, tuberculosis (TB) and hepatitis B virus (HBV) are major diseases among prison inmates. Objective: To determine overall and occult HBV infection (OBI) prevalence rates, risk factors and genotype distribution among inmates with active TB. Study Design: A cross-sectional study was conducted among 216 inmates with active TB recruited at the largest prisons in Campo Grande, Mato Grosso do Sul, Central Brazil. The participants were interviewed and tested for the presence of serological markers for HBV infection. Results: The overall prevalence of HBV infection (total hepatitis B core antibodies) was 10.2% (95%CI 6.2-14.2). HBV surface antigen (HBsAg) prevalence was 1.4% (3/216). HBV DNA was detected in all three HBsAg-positive samples and in 10.5% (2/19) of the anti-HBc-positive samples (OBI), giving a HBV-TB co-infection prevalence of 2.3% (5/216). A multivariate analysis of risk factors showed that history of sharing cutting instruments, length of incarceration and homosexual sex were associated with HBV infection. Conclusion: Our findings indicate that HBV remains an important public health concern among prison inmates and active TB-HBV co-infection needs to be addressed for effective treatment.
Databáze:	MEDLINE
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