Large scale accelerator production of 225 Ac: Effective cross sections for 78-192MeV protons incident on 232 Th targets.

Autor: Griswold JR; Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States; Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996, United States., Medvedev DG; Collider-Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, United States., Engle JW; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., Copping R; Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States., Fitzsimmons JM; Collider-Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, United States., Radchenko V; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., Cooley JC; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., Fassbender ME; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., Denton DL; Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States., Murphy KE; Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States., Owens AC; Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States., Birnbaum ER; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., John KD; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., Nortier FM; Los Alamos National Laboratory, Los Alamos, NM 87545, United States., Stracener DW; Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States., Heilbronn LH; Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996, United States., Mausner LF; Collider-Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, United States., Mirzadeh S; Nuclear Security and Isotope Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2016 Dec; Vol. 118, pp. 366-374. Date of Electronic Publication: 2016 Sep 28.
DOI: 10.1016/j.apradiso.2016.09.026
Abstrakt: Actinium-225 and 213 Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of 225 Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of 225 Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL). Excitation functions for actinium and thorium isotopes, as well as for some of the fission products, are presented. The cross sections for production of 225 Ac range from 3.6 to 16.7mb in the incident proton energy range of 78-192MeV. Based on these data, production of curie quantities of 225 Ac is possible by irradiating a 5.0gcm -2 232 Th target for 10 days in either BNL or LANL proton irradiation facilities.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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