Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead.

Autor:	Terakado M; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Suzuki H; Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd. , 17-2 Wadai, Tsukuba, Ibaraki 300-4247, Japan., Hashimura K; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Tanaka M; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Ueda H; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Kohno H; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Fujimoto T; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Saga H; Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd. , 17-2 Wadai, Tsukuba, Ibaraki 300-4247, Japan., Nakade S; Exploratory Research Laboratories, ONO Pharmaceutical Co., Ltd. , 17-2 Wadai, Tsukuba, Ibaraki 300-4247, Japan., Habashita H; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Takaoka Y; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan., Seko T; Medicinal Chemistry Research Laboratories, ONO Pharmaceutical Co., Ltd. , 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan.
Jazyk:	angličtina
Zdroj:	ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Aug 19; Vol. 7 (10), pp. 913-918. Date of Electronic Publication: 2016 Aug 19 (Print Publication: 2016).
DOI:	10.1021/acsmedchemlett.6b00225
Abstrakt:	Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA 1-6 . A high throughput screen against LPA 1 gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-7300243 ( 17a ) as a novel, potent LPA 1 antagonist, which showed good efficacy in vivo . The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α 1 adrenoceptor antagonist tamsulosin, which is used in clinical practice to treat dysuria with benign prostatic hyperplasia (BPH). In contrast to tamsulosin, compound 17a had no impact on the mean blood pressure at this dose. These results suggest that LPA 1 antagonists could be used to treat BPH without affecting the blood pressure. Herein, we report the hit-to-lead optimization of a unique series of LPA 1 antagonists and their in vivo efficacy.
Databáze:	MEDLINE
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