Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α.
| Autor: | Adamovich Y; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001 Rehovot, Israel., Ladeuix B; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001 Rehovot, Israel., Golik M; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001 Rehovot, Israel., Koeners MP; School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol BS8 1TH, UK., Asher G; Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001 Rehovot, Israel. Electronic address: gad.asher@weizmann.ac.il. |
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| Jazyk: | angličtina |
| Zdroj: | Cell metabolism [Cell Metab] 2017 Jan 10; Vol. 25 (1), pp. 93-101. Date of Electronic Publication: 2016 Oct 20. |
| DOI: | 10.1016/j.cmet.2016.09.014 |
| Abstrakt: | The mammalian circadian system consists of a master clock in the brain that synchronizes subsidiary oscillators in peripheral tissues. The master clock maintains phase coherence in peripheral cells through systemic cues such as feeding-fasting and temperature cycles. Here, we examined the role of oxygen as a resetting cue for circadian clocks. We continuously measured oxygen levels in living animals and detected daily rhythms in tissue oxygenation. Oxygen cycles, within the physiological range, were sufficient to synchronize cellular clocks in a HIF1α-dependent manner. Furthermore, several clock genes responded to changes in oxygen levels through HIF1α. Finally, we found that a moderate reduction in oxygen levels for a short period accelerates the adaptation of wild-type but not of HIF1α-deficient mice to the new time in a jet lag protocol. We conclude that oxygen, via HIF1α activation, is a resetting cue for circadian clocks and propose oxygen modulation as therapy for jet lag. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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