C-H activation reactions as useful tools for medicinal chemists.
| Autor: | Caro-Diaz EJE; Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA., Urbano M; Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA., Buzard DJ; Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA., Jones RM; Medicinal Chemistry, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA 92102, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Nov 15; Vol. 26 (22), pp. 5378-5383. Date of Electronic Publication: 2016 Aug 11. |
| DOI: | 10.1016/j.bmcl.2016.06.036 |
| Abstrakt: | In recent years, there has been an exponential rise in the number of reports describing synthetic methods that utilize catalytic sp 3 and sp 2 C-H bond activation. Many have emerged as powerful synthetic tools for accessing biologically active motifs. Indeed, application to C-C and C-heteroatom bond formation, provides new directives for the construction of new pharmaceutical entities. Herein, we highlight some recent novel C-H activation processes that exemplify the utility of these transformations in medicinal chemistry. (Copyright © 2016 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect