| Autor: |
Gashnikova NM; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia. ngash@vector.nsc.ru., Zyryanova DP; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia., Astakhova EM; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia., Ivlev VV; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia., Gashnikova MP; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia., Moskaleva NV; Kemerovo Regional Center for Prevention and Control of AIDS and Infectious Diseases, Kemerovo, Russia., Aikin SS; Kemerovo Regional Center for Prevention and Control of AIDS and Infectious Diseases, Kemerovo, Russia., Bulatova TN; Kemerovo Regional Center for Prevention and Control of AIDS and Infectious Diseases, Kemerovo, Russia., Pustylnikov SV; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia.; Novosibirsk Tuberculosis Research Institute, Novosibirsk, Russia., Bocharov EF; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia., Totmenin AV; State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Oblast, Russia. |
| Abstrakt: |
Kemerovo Oblast (KO) has had the highest rate of HIV spread in Russia since 2011. The aim of this work was to study the genetic variation of HIV-1 in Kemerovo Oblast. Blood was sampled from a total of 91 HIV-positive antiretroviral-therapy-naïve individuals in 2013 (38) and 2015 (53). HIV-1 subtypes, pol gene drug resistance mutations, and viral tropism were analyzed. In 2013-2015, the prevalence of HIV-1 subtype A decreased in KO from 60.5 to 7.5 %. The samples collected in 2015 from the patients with newly diagnosed HIV demonstrate the current dominance of HIV-1 CRF63_02A1 (71.7 %) and HIV-1 URF63_A1 (20.8 %), their parental viruses being CRF63_02A1 and subtype A. The initially predominant genetic variant, HIV-1 subtype A, was replaced in KO. An unusually high incidence of HIV-1 unique recombinant forms is probably the result of HIV-1 CRF63_02A1 introduction in the group of injection drug users with the initial HIV-1 subtype A infection and the practice of risky behavior that promotes reinfection. HIV-1 CRF63_02A1, which recently emerged in Siberia, and its recombinant forms have an ever-increasing impact on the current HIV epidemic in Russia, making urgent the need for in-depth study of this HIV-1 genetic variant. |
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