In vitro evaluation of pyrethroid-mediated changes on neuronal burst parameters using microelectrode arrays.
| Autor: | Mohana Krishnan B; Department of Toxicology, International Institute of Biotechnology and Toxicology (IIBAT), Padappai-601301, Tamil Nadu, India. Electronic address: baskarmohanakrishnan@gmail.com., Prakhya BM; Department of Toxicology, International Institute of Biotechnology and Toxicology (IIBAT), Padappai-601301, Tamil Nadu, India. Electronic address: prakhya@yahoo.com. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Neurotoxicology [Neurotoxicology] 2016 Dec; Vol. 57, pp. 270-281. Date of Electronic Publication: 2016 Oct 13. |
| DOI: | 10.1016/j.neuro.2016.10.007 |
| Abstrakt: | Effects of pyrethroids (beta-cyfluthrin, bifenthrin, cypermethrin, deltamethrin, lambda-cyhalothrin, and permethrin) on the burst parameters (mean burst rate [MBR], percent spikes in burst [PSB], mean burst duration [MBD], mean spikes in burst [MSB], mean interspike interval in burst [MISIB], and mean interburst interval [MIBI]) have been investigated using the microelectrode array technique. Rat cortical neuronal networks (between 24 and 35 DIV) were exposed to the five accumulative concentrations of pyrethroids (0.01μM, 0.1μM, 1μM, 10μM, and 100μM) after initially recording the baseline activity. When compared to the baseline, the burst parameter that had undergone the most change (either increase/decrease) at the initial concentrations was MBR, followed by MIBI and PSB. The other burst parameters (MSB, MBD, and MISIB) did not undergo much change (either increase/decrease) by the pyrethroids at the initial concentrations when compared to the baseline. The MBR of all pyrethroids rose at initial concentrations followed by decrease at higher concentrations. A drop in the MIBI accompanied the rise in the MBR. The rank orders of relative potency of pyrethroids on the IC (Copyright © 2016 Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect