In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [ 11 C]ABP688 and [ 18 F]FPEB.

Autor: DeLorenzo C; 1 Department of Psychiatry, Stony Brook University, Stony Brook, USA.; 2 Department of Biomedical Engineering, Stony Brook University, Stony Brook, USA.; 3 Department of Psychiatry, Columbia University, New York, USA., Gallezot JD; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA., Gardus J; 1 Department of Psychiatry, Stony Brook University, Stony Brook, USA., Yang J; 5 Department of Preventive Medicine, Stony Brook University, Stony Brook, USA., Planeta B; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA., Nabulsi N; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA., Ogden RT; 3 Department of Psychiatry, Columbia University, New York, USA., Labaree DC; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA., Huang YH; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA., Mann JJ; 3 Department of Psychiatry, Columbia University, New York, USA., Gasparini F; 6 Novartis Institutes for Biomedical Research, Basel, Switzerland., Lin X; 3 Department of Psychiatry, Columbia University, New York, USA.; 7 Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, USA., Javitch JA; 3 Department of Psychiatry, Columbia University, New York, USA.; 7 Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, USA.; 8 Department of Pharmacology, Columbia University, New York, USA., Parsey RV; 1 Department of Psychiatry, Stony Brook University, Stony Brook, USA.; 2 Department of Biomedical Engineering, Stony Brook University, Stony Brook, USA.; 9 Department of Radiology, Stony Brook University, Stony Brook, USA., Carson RE; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.; 10 Department of Biomedical Engineering, Yale University, New Haven, USA., Esterlis I; 4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.; 11 Department of Psychiatry, Yale University, New Haven, USA.
Jazyk: angličtina
Zdroj: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Aug; Vol. 37 (8), pp. 2716-2727. Date of Electronic Publication: 2016 Jan 01.
DOI: 10.1177/0271678X16673646
Abstrakt: Positron emission tomography tracers [ 11 C]ABP688 and [ 18 F]FPEB target the metabotropic glutamate receptor subtype 5 providing quantification of the brain glutamatergic system in vivo. Previous [ 11 C]ABP688 positron emission tomography human test-retest studies indicate that, when performed on the same day, significant binding increases are observed; however, little deviation is reported when scans are >7 days apart. Due to the small cohorts examined previously (eight and five males, respectively), we aimed to replicate the same-day test-retest studies in a larger cohort including both males and females. Results confirmed large within-subject binding differences (ranging from -23% to 108%), suggesting that measurements are greatly affected by study design. We further investigated whether this phenomenon was specific to [ 11 C]ABP688. Using [ 18 F]FPEB and methodology that accounts for residual radioactivity from the test scan, four subjects were scanned twice on the same day. In these subjects, binding estimates increased between 5% and 39% between scans. Consistent with [ 11 C]ABP688, mean absolute test-retest variability was previously reported as <12% when scans were >21 days apart. This replication study and pilot extension to [ 18 F]FPEB suggest that observed within-day binding variation may be due to characteristics of mGluR5; for example, diurnal variation in mGluR5 may affect measurement of this receptor.
Databáze: MEDLINE
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