Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis.

Autor:	Díaz FC; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain., Sáez-González E; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain., Benlloch S; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain., Álvarez-Sotomayor D; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain., Conde I; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain., Polo B; Department of Paediatric Gastroenterology. La Fe University Hospital, Valencia. Spain., García M; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain., Rodríguez M; Department of Digestive Diseases. Liver Unit. Hospital General Universitario Alicante. Spain., Prieto M; Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain.
Jazyk:	angličtina
Zdroj:	Annals of hepatology [Ann Hepatol] 2016 Nov-Dec 2016; Vol. 15 (6), pp. 939-943.
DOI:	10.5604/16652681.1222114
Abstrakt:	Background and aims. Steroid-related hepatotoxicity has become one of the most relevant causes of drug induced liver cholestasis. Some patients do not improve after standard medical treatment (SMT) and may therefore require other approaches, like extracorporeal liver support. Material and Methods: We report four cases of patients with pruritus, abnormal liver function tests and biopsy-proven anabolic steroid-induced cholestasis who were unresponsive to SMT. They underwent treatment with albumin dialysis (Molecular Adsorbent Recirculating System -MARS®-). A minimum of two MARS sessions were performed. Results: After MARS® procedure, patients' symptoms improved, as well as liver function tests, thus avoiding liver transplantation. Conclusion: Albumin dialysis appears as a valuable therapeutic option for the management of anabolic steroid-induced cholestasis in patients that are unresponsive to SMT.
Databáze:	MEDLINE
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