A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.

Autor:	Oberle SG; Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland., Hanna-El-Daher L; Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland., Chennupati V; Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland., Enouz S; Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland., Scherer S; Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland., Prlic M; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA., Zehn D; Department of Medicine, Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland. Electronic address: dietmar.zehn@tum.de.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2016 Oct 11; Vol. 17 (3), pp. 627-635.
DOI:	10.1016/j.celrep.2016.09.072
Abstrakt:	Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact the repertoire of T cells responding to new antigens is still largely unknown. We demonstrate that even a minimum epitope overlap between infections strongly increases the activation threshold and narrows the diversity of T cells recruited in response to new antigens. Thus, minimal cross-reactivity between infections can significantly impact the outcome of a subsequent immune response. Interestingly, we found that non-transferrable memory T cells are most effective in raising the activation threshold. Our findings have implications for designing vaccines and suggest that vaccines meant to target low-affinity T cells are less effective when they contain a strong CD8 T cell epitope that has previously been encountered. (Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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