Antifungal activities of diphenyl diselenide and ebselen against echinocandin-susceptible and -resistant strains of Candida parapsilosis.

Autor:	Chassot F; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil., Pozzebon Venturini T; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil., Baldissera Piasentin F; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil., Morais Santurio J; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa, PR, Brazil., Estivalet Svidzinski TI; Postgraduate Program in Pharmacology, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil., Hartz Alves S; Postgraduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, RS, Brazil.
Jazyk:	angličtina
Zdroj:	The new microbiologica [New Microbiol] 2016 Oct; Vol. 39 (4), pp. 301-303. Date of Electronic Publication: 2016 Sep 13.
Abstrakt:	We evaluated the in vitro antifungal activity of diphenyl diselenide and ebselen against echinocandin-susceptible and -resistant strains of Candida parapsilosis using the broth microdilution method. Diphenyl diselenide (MIC range =1-8 µg/mL) and ebselen (MIC range =0.25-4 µg/mL) showed in vitro activity against echinocandin-susceptible isolates. However, ebselen also showed the highest antifungal activity against echinocandin-resistant strains (MIC range =0.06-4 µg/mL). This study demonstrated that the antifungal potential of diphenyl diselenide and ebselen deserves further investigation using in vivo experimental protocols.
Databáze:	MEDLINE
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