Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis.

Autor: Mañé-Martínez MA; Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: unitatem@bellvitgehospital.cat., Olsson B; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden., Bau L; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain., Matas E; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain., Cobo-Calvo Á; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain., Andreasson U; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden., Blennow K; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden., Romero-Pinel L; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain., Martínez-Yélamos S; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain., Zetterberg H; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Möndal, Sweden; Institute of Neurology, University College London, United Kingdom.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2016 Oct 15; Vol. 299, pp. 112-117. Date of Electronic Publication: 2016 Aug 24.
DOI: 10.1016/j.jneuroim.2016.08.004
Abstrakt: In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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