Tribenzyltin carboxylates as anticancer drug candidates: Effect on the cytotoxicity, motility and invasiveness of breast cancer cell lines.

Autor: Anasamy T; Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia., Thy CK; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia., Lo KM; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia; Research Centre for Crystalline Materials, Sunway University, 47500, Petaling Jaya, Selangor Darul Ehsan, Malaysia. Electronic address: kmlo42@gmail.com., Chee CF; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia., Yeap SK; Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia., Kamalidehghan B; Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, 1983963113, Tehran, Iran; Medical Genetics Department, National Institute for Genetic Engineering and Biotechnology (NIGEB), 1497716316, Tehran, Iran., Chung LY; Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: chungly@hotmail.com.
Jazyk: angličtina
Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2017 Jan 05; Vol. 125, pp. 770-783. Date of Electronic Publication: 2016 Sep 21.
DOI: 10.1016/j.ejmech.2016.09.061
Abstrakt: This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogenation of the benzyl ring improved the anticancer effects of the tribenzyltin compounds with the N,N-diisopropylcarbamothioylsulfanylacetate ligand. These compounds also demonstrated far greater anticancer effects and selectivity than cisplatin and doxorubicin, which provides a rationale for their further development as anticancer agents.
(Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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