Human Split-Thickness Skin Allograft from Brain-Dead Donors.

Autor:	Khodadadi A; Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran., Olang O; Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Makhllough A; Molecular and Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Nozary Heshmati B; Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran., Azmoudeh Ardalan F; Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran., Tavakoli SA; Iranian Tissue Bank Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	International journal of organ transplantation medicine [Int J Organ Transplant Med] 2016; Vol. 7 (3), pp. 188-191. Date of Electronic Publication: 2016 Aug 01.
Abstrakt:	Background: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. Objective: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits. Methods: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors. Results: On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15-20 days. Conclusion: Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns.
Databáze:	MEDLINE
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