Evaluation of mesoporous carbon aerogels as carriers of the non-steroidal anti-inflammatory drug ibuprofen.

Autor: Eleftheriadis GK; School of Pharmacy, Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, GR-54124, Greece., Filippousi M; EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium., Tsachouridou V; School of Pharmacy, Department of Pharmacology, Aristotle University of Thessaloniki, GR-54124, Greece; Foundation for Research and Technology, Hellas-Institute of Chemical Engineering and High Temperature Chemical Processes (FORTH/ICE-HT), P.O. Box 1414, GR-26504 Patras, Greece., Darda MA; School of Pharmacy, Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, GR-54124, Greece., Sygellou L; Foundation for Research and Technology, Hellas-Institute of Chemical Engineering and High Temperature Chemical Processes (FORTH/ICE-HT), P.O. Box 1414, GR-26504 Patras, Greece., Kontopoulou I; Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece., Bouropoulos N; Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece., Steriotis T; National Center for Scientific Research 'Demokritos', 15341 Agia Paraskevi Attikis, Greece., Charalambopoulou G; National Center for Scientific Research 'Demokritos', 15341 Agia Paraskevi Attikis, Greece., Vizirianakis IS; School of Pharmacy, Department of Pharmacology, Aristotle University of Thessaloniki, GR-54124, Greece., Van Tendeloo G; EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium., Fatouros DG; School of Pharmacy, Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, GR-54124, Greece. Electronic address: dfatouro@pharm.auth.gr.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2016 Dec 30; Vol. 515 (1-2), pp. 262-270. Date of Electronic Publication: 2016 Oct 04.
DOI: 10.1016/j.ijpharm.2016.10.008
Abstrakt: Towards the development of novel drug carriers for oral delivery of poorly soluble drugs mesoporous aerogel carbons (CAs), namely CA10 and CA20 with different pore sizes (10 and 20nm, respectively), were evaluated. The non-steroidal anti-inflammatory lipophilic compound ibuprofen was incorporated via passive loading. The drug loaded carbon aerogels were systemically investigated by means of High-Resolution Transmission Electron Microscopy (HR-TEM), Nitrogen physisorption studies, X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), X-ray photon electron spectroscopy (XPS) and ζ-potential studies. In vitro release studies were performed in simulated intestinal fluids reflecting both fasted (FaSSIF) and fed (FeSSIF) state conditions. Cytotoxicity studies were conducted with human intestinal cells (Caco-2). Drug was in an amorphous state in the pores of the carbon carrier as shown from the physicochemical characterization studies. The results showed marked differences in the release profiles for ibuprofen from the two aerogels in the media tested whereas in vitro toxicity profiles appear to be compatible with potential therapeutic applications at low concentrations.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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