Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model.

Autor: Mesquita A; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain.; b University of Cincinnati College of Medicine , Cincinnati , OH , USA., Cardenal-Muñoz E; c Départment de Biochimie , Faculté des Sciences, Université de Genève , Switzerland., Dominguez E; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain.; d Departamento de Genética Molecular , Instituto de Fisiología Celular, Universidad Nacional Autónoma de México , Mexico City , México., Muñoz-Braceras S; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain., Nuñez-Corcuera B; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain., Phillips BA; e Department of Biomedical Sciences , University of Sheffield , UK., Tábara LC; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain., Xiong Q; f Center for Biochemistry, Medical Faculty, University of Cologne , Cologne , Germany., Coria R; d Departamento de Genética Molecular , Instituto de Fisiología Celular, Universidad Nacional Autónoma de México , Mexico City , México., Eichinger L; f Center for Biochemistry, Medical Faculty, University of Cologne , Cologne , Germany., Golstein P; g Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2 , Inserm, U1104, CNRS UMR7280, Marseille , France., King JS; e Department of Biomedical Sciences , University of Sheffield , UK., Soldati T; c Départment de Biochimie , Faculté des Sciences, Université de Genève , Switzerland., Vincent O; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain., Escalante R; a Instituto de Investigaciones Biomédicas 'Alberto Sols' (CSIC-UAM) , Madrid , Spain.
Jazyk: angličtina
Zdroj: Autophagy [Autophagy] 2017 Jan 02; Vol. 13 (1), pp. 24-40. Date of Electronic Publication: 2016 Oct 07.
DOI: 10.1080/15548627.2016.1226737
Abstrakt: Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum. Since the publication of the first review describing the potential of D. discoideum in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in D. discoideum has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in D. discoideum. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in D. discoideum has evolved significantly and will surely enable and accelerate future research using this model.
Databáze: MEDLINE
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