Remission spectrometry for blood vessel detection during stereotactic biopsy of brain tumors.
Autor: | Markwardt NA; Laser-Forschungslabor, LIFE Center, University Hospital of Munich, Munich, Germany.; Department of Urology, University Hospital of Munich, Munich, Germany., Stepp H; Laser-Forschungslabor, LIFE Center, University Hospital of Munich, Munich, Germany.; Department of Urology, University Hospital of Munich, Munich, Germany., Franz G; Department of Applied Sciences and Mechatronics, Munich University of Applied Sciences, Munich, Germany., Sroka R; Laser-Forschungslabor, LIFE Center, University Hospital of Munich, Munich, Germany.; Department of Urology, University Hospital of Munich, Munich, Germany., Goetz M; MRC Systems GmbH, Heidelberg, Germany., Zelenkov P; Burdenko Neurosurgery Institute, Moscow, Russia., Rühm A; Laser-Forschungslabor, LIFE Center, University Hospital of Munich, Munich, Germany.; Department of Urology, University Hospital of Munich, Munich, Germany. |
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Jazyk: | angličtina |
Zdroj: | Journal of biophotonics [J Biophotonics] 2017 Aug; Vol. 10 (8), pp. 1080-1094. Date of Electronic Publication: 2016 Oct 07. |
DOI: | 10.1002/jbio.201600193 |
Abstrakt: | Stereotactic biopsy is used to enable diagnostic confirmation of brain tumors and treatment planning. Despite being a well-established technique, it is related to significant morbidity and mortality rates mostly caused by hemorrhages due to blood vessel ruptures. This paper presents a method of vessel detection during stereotactic biopsy that can be easily implemented by integrating two side-view fibers into a conventional side-cutting biopsy needle. Tissue within the needle window is illuminated through the first fiber; the second fiber detects the remitted light. By taking the ratio of the intensities at two wavelengths with strongly differing hemoglobin absorption, blood vessels can be recognized immediately before biopsy sampling. Via ray tracing simulations and phantom experiments, the dependency of the remission ratio R = I (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
Databáze: | MEDLINE |
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