Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease.
| Autor: | Dahlin A; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA., Weiss ST; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. Electronic address: scott.weiss@channing.harvard.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Immunology and allergy clinics of North America [Immunol Allergy Clin North Am] 2016 Nov; Vol. 36 (4), pp. 765-789. |
| DOI: | 10.1016/j.iac.2016.06.010 |
| Abstrakt: | Aspirin-exacerbated respiratory disease (AERD) severity and its clinical phenotypes are characterized by genetic variation within pathways for arachidonic acid metabolism, inflammation, and immune responses. Epigenetic effects, including DNA methylation and histone protein modification, contribute to regulation of many genes that contribute to inflammatory states in AERD. The development of noninvasive, predictive clinical tests using data from genetic, epigenetic, pharmacogenetic, and biomarker studies will improve precision medicine efforts for AERD and asthma treatment. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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