The epidemiology of pituitary adenomas in a community-based hospital: a retrospective single center study in Saudi Arabia.

Autor:	Aljabri KS; Khalid S. Aljabri, MD, FRCPC, Department of Endocrinology,, King Fahad Armed Forces Hospital,, PO Box 6572, Jeddah 24361,, Saudi Arabia, T: 966555544919, F: 966-22-576-0665, khalidsaljabri@yahoo.com, ORCID: http://orcid.org/000-0001-5831-5935., Bokhari SA, Assiri FY, Alshareef MA, Khan PM
Jazyk:	angličtina
Zdroj:	Annals of Saudi medicine [Ann Saudi Med] 2016 Sep-Oct; Vol. 36 (5), pp. 341-345.
DOI:	10.5144/0256-4947.2016.341
Abstrakt:	Background: Data on pituitary adenoma (PA) prevalence in Saudi Arabia are scarce. Objective: To estimate the epidemiology of PA in a well-defined population. Design: Retrospective analysis. Setting: Departments of Endocrinology and Radiology at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. Patients and Methods: Radiological and hormonal data of patients with pituitary adenoma by MRI were reviewed for the period January 2008 to December 2015. Main Outcome Measures: Prevalence of PA and hormonal abnormalities. Results: Of 537 patients; 249 subjects (46.4%), 70 (28.1%) males and 179 (71.9%) females, were diagnosed to have PA with mean age 36.3 (14.1) years. Microadenoma and macroadenoma were seen in 171 (69%) and 78 (31%) subjects, respectively. Microadenomas were more prevalent than macroadenomas (68.7% vs. 31.3%). Microadenomas were significantly more prevalent in females, 131 (73.2 %) vs. 40 (57.1%) whereas macroadenomas were significantly more prevalent in males, 30 (42.9%) vs. 48 (26.8%) (P < .001 for both comparisons). Patients with microadenomas were significantly younger than patients with macroadenomas (P < .0001). Advanced age was significantly associated with a larger PA size (r=0.39, P < .0002). Three types of hyperfunctioning PA were seen: prolactinoma, somatotroph adenoma, and corticotroph adenoma. Five types of hypofunctioning PA were seen: panhypopituitarism, secondary hypogonadism, growth hormone deficiency, central hypothroidism and central adrenal insufficiency. Non-functioning PA were within normal laboratory hormonal values in 2% of cases. Conclusion: Our study showed that the prevalence of PA was greater than previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of PA. Limitations: Clustering of cases within the study region might have affected estimates and limited study sample size.
Databáze:	MEDLINE
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