Slow wave sleep and accelerated forgetting.

Autor: Atherton KE; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Nobre AC; Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK., Lazar AS; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK., Wulff K; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Whittaker RG; Institute of Neuroscience, Newcastle University, Newcastle, UK., Dhawan V; Institute of Neuroscience, Newcastle University, Newcastle, UK., Lazar ZI; Department of Physics, Babes-Bolyai University, Cluj-Napoca, Romania., Zeman AZ; Cognitive and Behavioural Neurology, Peninsular Medical School, University of Exeter, UK., Butler CR; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: chris.butler@ndcn.ox.ac.uk.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2016 Nov; Vol. 84, pp. 80-89. Date of Electronic Publication: 2016 Sep 12.
DOI: 10.1016/j.cortex.2016.08.013
Abstrakt: We investigated whether the benefit of slow wave sleep (SWS) for memory consolidation typically observed in healthy individuals is disrupted in people with accelerated long-term forgetting (ALF) due to epilepsy. SWS is thought to play an active role in declarative memory in healthy individuals and, furthermore, electrographic epileptiform activity is often more prevalent during SWS than during wakefulness or other sleep stages. We studied the relationship between SWS and the benefit of sleep for memory retention using a word-pair associates task. In both the ALF and the healthy control groups, sleep conferred a memory benefit. However, the relationship between the amount of SWS and sleep-related memory benefits differed significantly between the groups. In healthy participants, the amount of SWS correlated positively with sleep-related memory benefits. In stark contrast, the more SWS, the smaller the sleep-related memory benefit in the ALF group. Therefore, contrary to its role in healthy people, SWS-associated brain activity appears to be deleterious for memory in patients with ALF.
(Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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