Effect of Granulocyte Colony-Stimulating Factor Immobilized by the Electron-Beam Synthesis Nanotechnology on Reparative Regeneration of Spermatogenous Tissue.

Autor: Borovskaya TG; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia. repropharm@yandex.ru., Dygai AM; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Shchemerova YA; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Kamalova SI; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Mashanova VA; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Vychuzhanina AV; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Poluektova ME; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Madonov PG; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Kinsht DN; E. D. Goldberg Institute of Pharmacology and Reparative Medicine, Tomsk, Russia., Goldberg VE; Tomsk Research Institute of Oncology, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Sep; Vol. 161 (5), pp. 683-686. Date of Electronic Publication: 2016 Oct 05.
DOI: 10.1007/s10517-016-3485-0
Abstrakt: Effectiveness of the granulocyte colony-stimulating factor immobilized by using electronbeam synthesis nanotechnology was investigated on the model of experimental testicular failure caused by the toxic effect on stem spermatogonia. Administration of the drug to experimental paclitaxel-treated animals increased the number of sources of the proliferative pool of spermatogenesis and its productivity. The effectiveness of immobilized granulocyte colony-stimulating factor was based on its ability to stimulate reparative regeneration of the spermatogenic tissue, which manifested in a decrease in spermatogenic layer maturity and increase in the number of microenvironment cells. Effectiveness of the immobilized form of the drug was superior to that of non-immobilized form.
Databáze: MEDLINE
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