Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.

Autor: Söderholm S; Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland. sandra.soderholm@helsinki.fi.; Finnish Institute of Occupational Health, Helsinki 00250, Finland. sandra.soderholm@helsinki.fi., Fu Y; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. yu.fu@helsinki.fi., Gaelings L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. lgaelings@stud.hs-bremen.de., Belanov S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. sergei.belanov@helsinki.fi., Yetukuri L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. yetulax@mappi.helsinki.fi., Berlinkov M; Institute of Mathematics and Computer Science, Ural Federal University, Yekaterinburg 620083, Russia. berlm@mail.ru., Cheltsov AV; Q-Mol L.L.C. in Silico Pharmaceuticals, San Diego, CA 92037, USA. anton.cheltsov@gmail.com., Anders S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. simon.anders@fimm.fi., Aittokallio T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. tero.aittokallio@fimm.fi.; Department of Mathematics and Statistics, University of Turku, Turku 20014, Finland. tero.aittokallio@fimm.fi., Nyman TA; Institute of Clinical Medicine, Oslo 0450, Norway. t.a.nyman@medisin.uio.no., Matikainen S; Finnish Institute of Occupational Health, Helsinki 00250, Finland. sampsa.matikainen@helsinki.fi.; Department of Rheumatology, Helsinki University Hospital, University of Helsinki, Helsinki 00015, Finland. sampsa.matikainen@helsinki.fi., Kainov DE; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki 00014, Finland. denis.kainov@helsinki.fi.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2016 Sep 29; Vol. 8 (10). Date of Electronic Publication: 2016 Sep 29.
DOI: 10.3390/v8100269
Abstrakt: Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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