Essential Oil of Thymus munbyanus subsp. coloratus from Algeria: Chemotypification and in vitro Biological Activities.
| Autor: | Bendif H; Laboratory of Ethnobotany and Natural Substances, Department of Natural Sciences, Ecole Normale Supérieure (ENS), Kouba, B.P N°92 Kouba 16308, Algiers, Algeria.; Natural and Life Sciences Department, Faculty of Sciences, Mohamed Boudiaf University, BP 166 M'sila 28000, M'sila, Algeria., Boudjeniba M; Laboratory of Ethnobotany and Natural Substances, Department of Natural Sciences, Ecole Normale Supérieure (ENS), Kouba, B.P N°92 Kouba 16308, Algiers, Algeria., Miara MD; Natural and Life Sciences Department, Faculty of Sciences, Mohamed Boudiaf University, BP 166 M'sila 28000, M'sila, Algeria., Biqiku L; School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy., Bramucci M; School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy., Lupidi G; School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy., Quassinti L; School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy., Vitali LA; School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy., Maggi F; School of Pharmacy, University of Camerino, via S. Agostino 1, IT-62032, Camerino, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2017 Mar; Vol. 14 (3). Date of Electronic Publication: 2017 Feb 16. |
| DOI: | 10.1002/cbdv.201600299 |
| Abstrakt: | Thymus munbyanus subsp. coloratus (Lamiaceae) is a small shrub endemic to Algeria and Morocco where is found in lawns, rockeries and mountainous regions. From a phytochemical point of view this taxon has never been characterized. In this work we have analysed the chemical compositions of the essential oils obtained from inflorescences and vegetative parts by GC/MS. A new chemotype, i.e. borneol-chemotype, was characterized for the first time in the species. Furthermore, we assessed the biological activities of essential oils, namely the antioxidant, antimicrobial and cytotoxicity on tumor cells that were evaluated by the DPPH, ABTS, and FRAP, disc diffusion, and MTT methods, respectively. Biological assays highlighted a moderate inhibitory effect on Staphylococcus aureus, Escherichia coli and Candida albicans (inhibition zone diameter in the range 9 - 10 mm), and noteworthy cytotoxicity on A375 human melanoma cells (IC (© 2017 Wiley-VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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