Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution.
| Autor: | Faria VG; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Martins NE; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Magalhães S; Centre for Ecology, Evolution and Environmental Changes (cE3c), Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Paulo TF; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Nolte V; Institut für Populationsgenetik, Vetmeduni Vienna, Wien, Austria., Schlötterer C; Institut für Populationsgenetik, Vetmeduni Vienna, Wien, Austria., Sucena É; Instituto Gulbenkian de Ciência, Oeiras, Portugal.; Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Teixeira L; Instituto Gulbenkian de Ciência, Oeiras, Portugal. |
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| Jazyk: | angličtina |
| Zdroj: | PLoS genetics [PLoS Genet] 2016 Sep 29; Vol. 12 (9), pp. e1006297. Date of Electronic Publication: 2016 Sep 29 (Print Publication: 2016). |
| DOI: | 10.1371/journal.pgen.1006297 |
| Abstrakt: | Microbial symbionts can modulate host interactions with biotic and abiotic factors. Such interactions may affect the evolutionary trajectories of both host and symbiont. Wolbachia protects Drosophila melanogaster against several viral infections and the strength of the protection varies between variants of this endosymbiont. Since Wolbachia is maternally transmitted, its fitness depends on the fitness of its host. Therefore, Wolbachia populations may be under selection when Drosophila is subjected to viral infection. Here we show that in D. melanogaster populations selected for increased survival upon infection with Drosophila C virus there is a strong selection coefficient for specific Wolbachia variants, leading to their fixation. Flies carrying these selected Wolbachia variants have higher survival and fertility upon viral infection when compared to flies with the other variants. These findings demonstrate how the interaction of a host with pathogens shapes the genetic composition of symbiont populations. Furthermore, host adaptation can result from the evolution of its symbionts, with host and symbiont functioning as a single evolutionary unit. Competing Interests: The authors have declared that no competing interests exist. |
| Databáze: | MEDLINE |
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