Headache Disorders May Be a Risk Factor for the Development of New Onset Hypothyroidism.

Autor: Martin AT; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Pinney SM; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Xie C; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Herrick RL; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Bai Y; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Buckholz J; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Martin VT; Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jazyk: angličtina
Zdroj: Headache [Headache] 2017 Jan; Vol. 57 (1), pp. 21-30. Date of Electronic Publication: 2016 Sep 27.
DOI: 10.1111/head.12943
Abstrakt: Objective: To determine whether headache disorders are a risk factor for the development of new onset hypothyroidism.
Background: Past studies have reported associations between headache disorders and hypothyroidism, but the directionality of the association is unknown.
Methods: This was a longitudinal retrospective cohort study using data from the Fernald Medical Monitoring Program (FMMP). Residents received physical examinations and thyroid function testing every 3 years during the 20 year program. Residents were excluded from the cohort if there was evidence of past thyroid disease or abnormal thyroid function tests at the first office visit. A diagnosis of a headache disorder was established by self-report of "frequent headaches," use of any headache-specific medication, or a physician diagnosis of a headache disorder. The primary outcome measure was new onset hypothyroidism defined as the initiation of thyroid replacement therapy or TSH ≥ 10 without thyroid medication. A Cox survival analysis with time dependent variables were used for the model. Headache disorders, age, sex, body mass index, income, smoking, narcotic use, and hypothyroidism-producing medications were independent variables in the model.
Results: Data from 8412 residents enrolled in the FMMP were used in the current study. Headache disorders were present in about 26% of the residents and new onset hypothyroidism developed in ∼7%. The hazard ratio for the development of new onset hypothyroidism was 1.21 (95% CI = 1.001, 1.462) for those with headache disorders.
Conclusions: Headache disorders may be associated with an increased risk for the development of new onset hypothyroidism.
(© 2016 American Headache Society.)
Databáze: MEDLINE
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