Simultaneous noninvasive recording of skin sympathetic nerve activity and electrocardiogram.
| Autor: | Doytchinova A; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Hassel JL; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Yuan Y; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Lin H; Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana., Yin D; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China., Adams D; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Straka S; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Wright K; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Smith K; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Wagner D; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Shen C; Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana., Salanova V; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana., Meshberger C; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana., Chen LS; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana., Kincaid JC; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana., Coffey AC; Division of Cardiothoracic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana., Wu G; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China., Li Y; Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China., Kovacs RJ; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Everett TH 4th; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Victor R; Cedars-Sinai Heart Institute/Hypertension Center(,) Los Angeles, California., Cha YM; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota., Lin SF; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Institute of Biomedical Engineering, National Chiao-Tung University, Hsin-Chu, Taiwan., Chen PS; Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: chenpp@iu.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Heart rhythm [Heart Rhythm] 2017 Jan; Vol. 14 (1), pp. 25-33. Date of Electronic Publication: 2016 Sep 23. |
| DOI: | 10.1016/j.hrthm.2016.09.019 |
| Abstrakt: | Background: Sympathetic nerve activity is important to cardiac arrhythmogenesis. Objective: The purpose of this study was to develop a method for simultaneous noninvasive recording of skin sympathetic nerve activity (SKNA) and electrocardiogram (ECG) using conventional ECG electrodes. This method (neuECG) can be used to adequately estimate sympathetic tone. Methods: We recorded neuECG signals from the skin of 56 human subjects. The signals were low-pass filtered to show the ECG and high-pass filtered to show nerve activity. Protocol 1 included 12 healthy volunteers who underwent cold water pressor test and Valsalva maneuver. Protocol 2 included 19 inpatients with epilepsy but without known heart diseases monitored for 24 hours. Protocol 3 included 22 patients admitted with electrical storm and monitored for 39.0 ± 28.2 hours. Protocol 4 included 3 patients who underwent bilateral stellate ganglion blockade with lidocaine injection. Results: In patients without heart diseases, spontaneous nerve discharges were frequently observed at baseline and were associated with heart rate acceleration. SKNA recorded from chest leads (V Conclusion: SKNA is detectable using conventional ECG electrodes in humans and may be useful in estimating sympathetic tone. Competing Interests: Shien-Fong Lin and Peng-Sheng Chen have equity interest in Arrhythmotech, LLC. Medtronic, St Jude and Cyberonics Inc. donated research equipment to Dr Chen’s research laboratory. (Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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