Genetic variation may explain why females are less susceptible to dental erosion.

Autor: Uhlen MM; Faculty of Dentistry, Department of Cariology and Gerodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway. m.m.n.uhlen@odont.uio.no., Stenhagen KR; Faculty of Dentistry, Department of Cariology and Gerodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway., Dizak PM; Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Holme B; SINTEF Materials and Chemistry, Oslo, Norway., Mulic A; Faculty of Dentistry, Department of Cariology and Gerodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway., Tveit AB; Faculty of Dentistry, Department of Cariology and Gerodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway., Vieira AR; Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: European journal of oral sciences [Eur J Oral Sci] 2016 Oct; Vol. 124 (5), pp. 426-432. Date of Electronic Publication: 2016 Sep 26.
DOI: 10.1111/eos.12297
Abstrakt: Not all individuals at risk for dental erosion (DE) display erosive lesions. The prevalence of DE is higher among male subjects. The occurrence of DE may depend on more than just acidic challenge, with genetics possibly playing a role. The aim of this study was to investigate the association of enamel-formation genes with DE. One premolar and a saliva sample were collected from 90 individuals. Prepared teeth were immersed in 0.01 M HCl (pH 2.2), and enamel loss (μm) was measured using white light interferometry. DNA was extracted from saliva, and 15 single-nucleotide polymorphisms were analysed. Allele and genotype frequencies were related to the enamel loss of the specimens. Single-marker and haplotype analyses were performed using sex as a covariate. Mean enamel loss was higher for male donors than for female donors (P = 0.047). Significant associations were found between enamel loss and amelogenin, X-linked (AMELX), tuftelin 1 (TUFT1), and tuftelin-interacting protein 11 (TFIP11). Analyses showed significant associations between variation in enamel-formation genes and a lower susceptibility to DE in female subjects. The results indicate that susceptibility to DE is influenced by genetic variation, and may, in part, explain why some individuals are more susceptible than others to DE, including differences between female subjects and male subjects.
(© 2016 Eur J Oral Sci.)
Databáze: MEDLINE
Externí odkaz: