Influence of cigarette smoking on ALS outcome: a population-based study.

Autor:	Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Canosa A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Bertuzzo D; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Cugnasco P; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Solero L; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Clerico M; Department of Biological and Clinical Science, University of Turin, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy., De Mercanti S; Department of Biological and Clinical Science, University of Turin, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy., Bersano E; Department of Neurology, ALS Center, Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy Eastern Piedmont University, Novara, Italy., Cammarosano S; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Ilardi A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Manera U; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy., Marinou K; Salvatore Maugeri Foundation, IRCSS, Scientific Institute of Milano, Milano, Italy., Bottacchi E; Department of Neurology, Azienda Ospedaliera Regionale di Aosta, Azienda USL Valle d'Aosta, Aosta, Italy., Pisano F; Salvatore Maugeri Foundation, IRCSS, Scientific Institute of Veruno (NO), Veruno, Italy., Mora G; Salvatore Maugeri Foundation, IRCSS, Scientific Institute of Milano, Milano, Italy., Mazzini L; Department of Neurology, ALS Center, Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Turin, Turin, Italy Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy Neuroscience Institute of Torino (NIT), Turin, Italy.
Jazyk:	angličtina
Zdroj:	Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2016 Nov; Vol. 87 (11), pp. 1229-1233. Date of Electronic Publication: 2016 Sep 21.
DOI:	10.1136/jnnp-2016-313793
Abstrakt:	Objective: To assess the prognostic influence of premorbid smoking habits and vascular risk profile on amyotrophic lateral sclerosis (ALS) phenotype and outcome in a population-based cohort of Italian patients. Methods: A total of 650 patients with ALS from the Piemonte/Valle d'Aosta Register for ALS, incident in the 2007-2011 period, were recruited. Information about premorbid cigarette smoking habits and chronic obstructive pulmonary disease (COPD) were collected at the time of diagnosis. Results: Current smokers had a significantly shorter median survival (1.9 years, IQR 1.2-3.4) compared with former (2.3 years, IQR 1.5-4.2) and never smokers (2.7 years, IQR 1.8-4.6) (p=0.001). Also COPD adversely influenced patients' prognosis. Both smoking habits and CODP were retained in Cox multivariable model. Conclusions: This study has demonstrated in a large population-based cohort of patients with ALS that cigarette smoking is an independent negative prognostic factor for survival, with a dose-response gradient. Its effect is not related to the presence of COPD or to respiratory status at time of diagnosis. The understanding of the mechanisms, either genetic or epigenetic, through which exogenous factors influence disease phenotype is of major importance towards a more focused approach to cure ALS. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
Databáze:	MEDLINE
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