Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia.

Autor: Ivanova SA; a Mental Health Research Institute , Tomsk , Russian Federation.; b National Research Tomsk Polytechnic University , Tomsk , Russian Federation., Osmanova DZ; a Mental Health Research Institute , Tomsk , Russian Federation.; c National Research Tomsk State University , Tomsk , Russian Federation., Freidin MB; d Department of Twin Research and Genetic Epidemiology , King's College London , London , UK.; e Research Institute for Medical Genetics , Tomsk , Russian Federation., Fedorenko OY; a Mental Health Research Institute , Tomsk , Russian Federation.; b National Research Tomsk Polytechnic University , Tomsk , Russian Federation., Boiko AS; a Mental Health Research Institute , Tomsk , Russian Federation., Pozhidaev IV; a Mental Health Research Institute , Tomsk , Russian Federation.; c National Research Tomsk State University , Tomsk , Russian Federation., Semke AV; a Mental Health Research Institute , Tomsk , Russian Federation., Bokhan NA; a Mental Health Research Institute , Tomsk , Russian Federation.; c National Research Tomsk State University , Tomsk , Russian Federation., Agarkov AA; a Mental Health Research Institute , Tomsk , Russian Federation., Wilffert B; f Department of Pharmacy , University of Groningen , Groningen , The Netherlands.; g Department of Clinical Pharmacy and Pharmacology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands., Loonen AJ; g Department of Clinical Pharmacy and Pharmacology , University of Groningen, University Medical Center Groningen , Groningen , The Netherlands.; h GGZ Westelijk Noord-Brabant , Bergen op Zoom , The Netherlands.
Jazyk: angličtina
Zdroj: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2017 Apr; Vol. 18 (3), pp. 239-246. Date of Electronic Publication: 2016 Sep 22.
DOI: 10.1080/15622975.2016.1224926
Abstrakt: Objectives: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT).
Methods: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs.
Results: None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL.
Conclusions: This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms.
Databáze: MEDLINE
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