Detection of Occult Acute Kidney Injury in Glucose-6-Phosphate Dehydrogenase Deficiency Anemia.

Autor: Abdel Hakeem GL; Pediatric Department, Minia University, Egypt., Abdel Naeem EA; Clinical Pathology Department, Minia University, Egypt., Swelam SH; Pediatric Department, Minia University, Egypt., El Morsi Aboul Fotoh L; Pediatric Department, Minia University, Egypt., El Mazary AA; Pediatric Department, Minia University, Egypt., Abdel Fadil AM; Pediatric Department, Minia University, Egypt., Abdel Hafez AH; Pediatric Department, Minia University, Egypt.
Jazyk: angličtina
Zdroj: Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2016 Aug 20; Vol. 8 (1), pp. e2016038. Date of Electronic Publication: 2016 Aug 20 (Print Publication: 2016).
DOI: 10.4084/MJHID.2016.038
Abstrakt: Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia is associated with intravascular hemolysis. The freely filtered hemoglobin can damage the kidney. We aimed to assess any subclinical renal injury in G6PD children.
Methods: Sixty children were included. Thirty G6PD deficiency anemia children were enrolled during the acute hemolytic crisis and after the hemolytic episode had elapsed. Another thirty healthy children were included as controls. Serum cystatin C, creatinine levels, and urinary albumin/creatinine (A/C) ratio were measured, and the glomerular filtration rate (GFR) was calculated.
Results: Significantly higher urinary A/C ratio (p=0.001,0.002 respectively) and lower GFR (p=0.001 for both) were found during hemolysis and after the hemolytic episode compared to the controls. Also, significant higher serum cystatin C (p=0.001), creatinine (p=0.05) and A/C (p= 0.001) ratio and insignificant lower GFR (p=0.3) during acute hemolytic crisis compared to the same children after the hemolytic episode subsided.
Conclusions: G6PD deficiency anemia is associated with a variable degree of acute renal injury during acute hemolytic episodes which may persist after elapsing of the hemolytic crises.
Databáze: MEDLINE
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