Circulating Fibronectin and Plasminogen Activator Inhibitor-2 Levels as Possible Predictors of Recurrent Placental Syndrome: An Exploratory Study.
| Autor: | Severens-Rijvers CAH; Department of Pathology, Maastricht University Medical Centre, CAPHRI Research School, The Division 'Vrouw & Baby', Maastricht, The Netherlands., Al-Nasiry S, Ghossein-Doha C, Marzano S, Ten Cate H, Winkens B, Spaanderman MAE, Peeters LLH |
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| Jazyk: | angličtina |
| Zdroj: | Gynecologic and obstetric investigation [Gynecol Obstet Invest] 2017; Vol. 82 (4), pp. 355-360. Date of Electronic Publication: 2016 Sep 20. |
| DOI: | 10.1159/000449385 |
| Abstrakt: | Background/aim: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). Methods: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy. Differences were analyzed between pregnancies with rPS (n = 12) and without rPS (non-rPS, n = 24) using linear mixed models, with subanalyses based on pre-pregnant normal or subnormal PV. Results: We observed higher fibronectin-levels at 12-16 weeks (p < 0.05 and p < 0.01, respectively) and lower PAI-2-levels at 16 weeks (p < 0.01) in the rPS subgroup, the intergroup differences being larger in women with subnormal PV. Conclusion: We showed that former PS patients who developed rPS have raised fibronectin- and reduced PAI-2-levels already in early/mid pregnancy. These deviations are even more prominent in women with subnormal pre-pregnant PV, supporting development of a 2-step screening program for former patients to identify the high-risk subgroup of women who may benefit from closer surveillance. (© 2016 The Author(s) Published by S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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