Oral acute and subchronic toxicity studies of the oil extracted from pequi (Caryocar brasiliense, Camb.) pulp in rats.

Autor: Traesel GK; Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil. Electronic address: giselitraesel@gmail.com., Menegati SE; Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Dos Santos AC; Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Carvalho Souza RI; Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Villas Boas GR; Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Justi PN; Faculty of Exact Sciences and Technology, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Kassuya CA; Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Sanjinez Argandoña EJ; Faculty of Exact Sciences and Technology, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil., Oesterreich SA; Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2016 Nov; Vol. 97, pp. 224-231. Date of Electronic Publication: 2016 Sep 14.
DOI: 10.1016/j.fct.2016.09.018
Abstrakt: The Caryocar brasiliense (pequi) is a Brazilian fruit of important geographic distribution and of broad popular use for nutritional purposes. This study aimed to evaluate the toxicological potential of pequi through the acute and subchronic toxicity tests. For the acute toxicity test, female Wistar rats received, orally, a single dose of 2000 mg/kg/bw of pequi oil and were observed for 14 days. In subchronic toxicity test, Wistar male and female rats received, orally, repeated doses of 125, 250, 500 or 1000 mg/kg/bw of the oil, being treated and observed for 28 days. In the acute toxicity test, no changes as well as no mortality were observed, indicating that the LD 50 is higher than 2000 mg/kg/bw. In the subchronic toxicity test, the tested doses produced no significant changes in behavioral, physiological, biochemical or histopathologic parameters in animals. Some hematological abnormalities were found after subchronic exposure and need to be clarified. These results demonstrate the low toxicity of acute and subchronic to the oil of pequi in rats. However, additional studies are required in order to verify if the hematological abnormalities have any relation to the oil exposure and also provide sufficient safety evidence for the use of the oil in humans.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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