Hypophyseal metastases: A report of three cases and literature review.

Autor:	Ravnik J; Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia., Smigoc T; Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia., Bunc G; Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia., Lanisnik B; Department of Ears, Nose and Throat, University Medical Centre Maribor, Maribor, Slovenia., Ksela U; Department of Endocrinology, University Medical Centre Maribor, Maribor, Slovenia., Ravnik M; Department of Oncology, University Medical Centre Maribor, Maribor, Slovenia., Velnar T; Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia. Electronic address: tvelnar@hotmail.com.
Jazyk:	angličtina
Zdroj:	Neurologia i neurochirurgia polska [Neurol Neurochir Pol] 2016 Nov - Dec; Vol. 50 (6), pp. 511-516. Date of Electronic Publication: 2016 Sep 04.
DOI:	10.1016/j.pjnns.2016.08.007
Abstrakt:	Metastatic tumours to the pituitary gland are rare. The most frequent are metastases from breast and lung. We describe three patients with metastatic tumours: (I) a 54-year-old patient with metastatic renal clear-cell carcinoma and consequent disturbances in visual acuity, cranial nerve paresis and panhypopituitarism, (II) a 60-year-old patient with a diffuse large B-cell lymphoma with panhypopituitarism and diabetes insipidus and (III) a 57-year-old patient with metastasis of breast cancer and panhypopituitarism, visual impairment and cranial nerve paresis. A transnasal endoscopic biopsy and resection of the tumour was performed in all patients, followed by the oncological treatment. Despite the rarity of the disease, it is important to suspect a metastatic pituitary tumour especially in the case of diabetes insipidus, ophthalmoplegia, rapid course of the disease and headaches. In 20-30% of patients, a metastasis to the pituitary is the first manifestation of a tumour of unknown origin. Surgical and adjuvant therapy may improve the quality of life. The survival is not affected, however, and the prognosis of the disease is usually poor. (Copyright © 2016 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.)
Databáze:	MEDLINE
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