| Autor: |
Chung MK, White PS, Lee SJ; U.S. Army Research Office , P.O. Box 12211, Research Triangle Park, North Carolina 27709, United States., Gagné MR, Waters ML |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2016 Oct 12; Vol. 138 (40), pp. 13344-13352. Date of Electronic Publication: 2016 Sep 29. |
| DOI: |
10.1021/jacs.6b07833 |
| Abstrakt: |
We report a functional synthetic model for studying the noncovalent networks (NCNs) required for complex protein functions. The model [2]-catenane is self-assembled from dipeptide building blocks and contains an extensive network of hydrogen bonds and aromatic interactions. Perturbations to the catenane cause compensating changes in the NCNs structure and dynamics, resulting in long-distance changes reminiscent of a protein. Key findings include the notion that NCNs require regions of negative cooperativity, or "frustrated" noncovalent interactions, as a source of potential energy for driving the response. We refer to this potential energy as latent free energy and describe a mechanistic and energetic model for responsive systems. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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