Linking the Microbiota, Chronic Disease, and the Immune System.

Autor: Hand TW; Richard King Mellon Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA 15224, USA. Electronic address: timothy.hand@chp.edu., Vujkovic-Cvijin I; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), Bethesda, MD 20892, USA., Ridaura VK; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), Bethesda, MD 20892, USA., Belkaid Y; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH), Bethesda, MD 20892, USA; National Institute of Allergy and Infectious Diseases (NIAID) Microbiome Program, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Jazyk: angličtina
Zdroj: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2016 Dec; Vol. 27 (12), pp. 831-843. Date of Electronic Publication: 2016 Sep 10.
DOI: 10.1016/j.tem.2016.08.003
Abstrakt: Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many CIDs are associated with significant shifts in the microbiota toward inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites. This review discusses recent findings suggesting that shifts in the microbiota may contribute to chronic disease via effects on the immune system.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: