Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series.

Autor: Peçanha PM; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., de Souza S; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Falqueto A; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Grão-Veloso TR; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Lírio LV; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Ferreira CU Jr; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Santos AR; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Costa HG; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., de Souza LR; Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Tuon FF; Department of Medicine, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil; Division of Infectious Diseases, Universidade Federal do Parana, Curitiba, PR, Brazil. Electronic address: flptuon@gmail.com.
Jazyk: angličtina
Zdroj: International journal of antimicrobial agents [Int J Antimicrob Agents] 2016 Oct; Vol. 48 (4), pp. 428-30. Date of Electronic Publication: 2016 Jul 19.
DOI: 10.1016/j.ijantimicag.2016.06.011
Abstrakt: Amphotericin B deoxycholate is the main option for intravenous (i.v.) treatment of severe paracoccidioidomycosis (PCM). This is the first report of amphotericin B lipid complex (ABLC) in the treatment of PCM. Among 28 patients, cure was achieved in all patients (100%) using ABLC. Mean and median daily doses of ABLC were 3.39 mg/kg/day and 3.35 mg/kg/day, respectively. ABLC may be a choice in the treatment of severe forms of PCM or when i.v. options are required.
(Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.)
Databáze: MEDLINE
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